PROCYANIDIN OLIGOMERS FOR INHIBITING MATRIX METALLOPROTEINASES AND MEDICINE HAVING EFFECTIVE COMPOSITION OF SAME

The present invention provides procyanidin oligomers with significant biological activity against matrix metalloproteinase (MMP). The procyanidin oligomers can be isolated from the genus Ulmus and other plants and comprise trimeric through dodecameric procyanidin oligomers of flavan-3-ol monomer uni...

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Bibliographische Detailangaben
1. Verfasser:	KIM, SANG-NYUN
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides procyanidin oligomers with significant biological activity against matrix metalloproteinase (MMP). The procyanidin oligomers can be isolated from the genus Ulmus and other plants and comprise trimeric through dodecameric procyanidin oligomers of flavan-3-ol monomer units. The present invention encompasses methods of using the procyanidin oligomer in treating tumor metastasis or invasion, rheumatoid arthritis, diabetes, corneal, epidermal, and gastric ulceration, skin wrinkling, periodontitis, osteoporosis; and in the promotion of wound and burn healing and other related maladies in which uncontrolled high levels of MMP are thought to play an important role in the malady progress.