ANTIPSYCHOTIC CYCLIC N-ARALKYL AMINES
The invention concerns antipsychotic compounds of formula (I) wherein: A represents a group selected among the following: -C=C-; -CH=CH-; -CH2-CH2-; n is equal to 1 or 2; X represents a hydrogen, chlorine or fluorine atom, a methyl or methoxy group; Y represents a hydrogen atom or a chlorine or a fl...
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| creator | BOIGEGRAIN, ROBERT |
| description | The invention concerns antipsychotic compounds of formula (I) wherein: A represents a group selected among the following: -C=C-; -CH=CH-; -CH2-CH2-; n is equal to 1 or 2; X represents a hydrogen, chlorine or fluorine atom, a methyl or methoxy group; Y represents a hydrogen atom or a chlorine or a fluorine atom; R1 represents a cyclohexyl, phenyl, cycloheptyl, tertiary butyl, dicyclopropylmethyl, bicyclo[3.2.1]octanyl, 4-tetrahydropyranyl, 4-tetrahydrothiopyranyl or adamantyle group; R2 and R3 form together with the nitrogen atom whereto they re bound a cyclic amine; and the additive salts of said compounds with pharmaceutically acceptable acids, as well as their solvates and hydrates.
La invencion concierne a compuestos antipsicoticos de la formula (1) en donde: A. representa un grupo elegido entre los siguientes: -C?C-; -CH=CH-, -CH2-CH2-; n es igual a 1 o 2; X representa un atomo de hidrogeno, de cloro o de fluor o un grupo metilo o metoxi; Y representa un atomo de hidrogeno o un atomo de cloro o de fluor; R1 representa un grupo ciclohexilo, fenilo, cicloheptilo, butilo terciario, diciclopropilmetilo, biciclo[3.2.1? octanilo, 4-tetrahidropiranilo, 4-tetrahidrotiopiranilo o adamantilo, R2 y R3 forman con el atomo de nitrogeno al cual estan unidos una amina ciclica; y las sales de adicion de esos compuestos con acidos farmaceuticamente aceptables, asi como sus solvatos e hidratos. |
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La invencion concierne a compuestos antipsicoticos de la formula (1) en donde: A. representa un grupo elegido entre los siguientes: -C?C-; -CH=CH-, -CH2-CH2-; n es igual a 1 o 2; X representa un atomo de hidrogeno, de cloro o de fluor o un grupo metilo o metoxi; Y representa un atomo de hidrogeno o un atomo de cloro o de fluor; R1 representa un grupo ciclohexilo, fenilo, cicloheptilo, butilo terciario, diciclopropilmetilo, biciclo[3.2.1? octanilo, 4-tetrahidropiranilo, 4-tetrahidrotiopiranilo o adamantilo, R2 y R3 forman con el atomo de nitrogeno al cual estan unidos una amina ciclica; y las sales de adicion de esos compuestos con acidos farmaceuticamente aceptables, asi como sus solvatos e hidratos.</description><edition>A</edition><language>eng ; spa</language><subject>APPARATUS THEREFOR ; CHEMISTRY ; GENERAL METHODS OF ORGANIC CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2002</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020621&DB=EPODOC&CC=MX&NR=PA01013207A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20020621&DB=EPODOC&CC=MX&NR=PA01013207A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BOIGEGRAIN, ROBERT</creatorcontrib><title>ANTIPSYCHOTIC CYCLIC N-ARALKYL AMINES</title><description>The invention concerns antipsychotic compounds of formula (I) wherein: A represents a group selected among the following: -C=C-; -CH=CH-; -CH2-CH2-; n is equal to 1 or 2; X represents a hydrogen, chlorine or fluorine atom, a methyl or methoxy group; Y represents a hydrogen atom or a chlorine or a fluorine atom; R1 represents a cyclohexyl, phenyl, cycloheptyl, tertiary butyl, dicyclopropylmethyl, bicyclo[3.2.1]octanyl, 4-tetrahydropyranyl, 4-tetrahydrothiopyranyl or adamantyle group; R2 and R3 form together with the nitrogen atom whereto they re bound a cyclic amine; and the additive salts of said compounds with pharmaceutically acceptable acids, as well as their solvates and hydrates.
La invencion concierne a compuestos antipsicoticos de la formula (1) en donde: A. representa un grupo elegido entre los siguientes: -C?C-; -CH=CH-, -CH2-CH2-; n es igual a 1 o 2; X representa un atomo de hidrogeno, de cloro o de fluor o un grupo metilo o metoxi; Y representa un atomo de hidrogeno o un atomo de cloro o de fluor; R1 representa un grupo ciclohexilo, fenilo, cicloheptilo, butilo terciario, diciclopropilmetilo, biciclo[3.2.1? octanilo, 4-tetrahidropiranilo, 4-tetrahidrotiopiranilo o adamantilo, R2 y R3 forman con el atomo de nitrogeno al cual estan unidos una amina ciclica; y las sales de adicion de esos compuestos con acidos farmaceuticamente aceptables, asi como sus solvatos e hidratos.</description><subject>APPARATUS THEREFOR</subject><subject>CHEMISTRY</subject><subject>GENERAL METHODS OF ORGANIC CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2002</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFB19AvxDAiOdPbwD_F0VnCOdPYBUn66jkGOPt6RPgqOvp5-rsE8DKxpiTnFqbxQmptByc01xNlDN7UgPz61uCAxOTUvtSTeNyLA0cDQwNDYyMDc0ZgoRQD26iQV</recordid><startdate>20020621</startdate><enddate>20020621</enddate><creator>BOIGEGRAIN, ROBERT</creator><scope>EVB</scope></search><sort><creationdate>20020621</creationdate><title>ANTIPSYCHOTIC CYCLIC N-ARALKYL AMINES</title><author>BOIGEGRAIN, ROBERT</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MXPA01013207A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2002</creationdate><topic>APPARATUS THEREFOR</topic><topic>CHEMISTRY</topic><topic>GENERAL METHODS OF ORGANIC CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BOIGEGRAIN, ROBERT</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BOIGEGRAIN, ROBERT</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTIPSYCHOTIC CYCLIC N-ARALKYL AMINES</title><date>2002-06-21</date><risdate>2002</risdate><abstract>The invention concerns antipsychotic compounds of formula (I) wherein: A represents a group selected among the following: -C=C-; -CH=CH-; -CH2-CH2-; n is equal to 1 or 2; X represents a hydrogen, chlorine or fluorine atom, a methyl or methoxy group; Y represents a hydrogen atom or a chlorine or a fluorine atom; R1 represents a cyclohexyl, phenyl, cycloheptyl, tertiary butyl, dicyclopropylmethyl, bicyclo[3.2.1]octanyl, 4-tetrahydropyranyl, 4-tetrahydrothiopyranyl or adamantyle group; R2 and R3 form together with the nitrogen atom whereto they re bound a cyclic amine; and the additive salts of said compounds with pharmaceutically acceptable acids, as well as their solvates and hydrates.
La invencion concierne a compuestos antipsicoticos de la formula (1) en donde: A. representa un grupo elegido entre los siguientes: -C?C-; -CH=CH-, -CH2-CH2-; n es igual a 1 o 2; X representa un atomo de hidrogeno, de cloro o de fluor o un grupo metilo o metoxi; Y representa un atomo de hidrogeno o un atomo de cloro o de fluor; R1 representa un grupo ciclohexilo, fenilo, cicloheptilo, butilo terciario, diciclopropilmetilo, biciclo[3.2.1? octanilo, 4-tetrahidropiranilo, 4-tetrahidrotiopiranilo o adamantilo, R2 y R3 forman con el atomo de nitrogeno al cual estan unidos una amina ciclica; y las sales de adicion de esos compuestos con acidos farmaceuticamente aceptables, asi como sus solvatos e hidratos.</abstract><edition>A</edition><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ANTIPSYCHOTIC CYCLIC N-ARALKYL AMINES |
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