TRANSGENIC ANIMALS PRODUCING OLIGOSACCHARIDES AND GLYCOCONJUGATES

The invention relates to transgenic non-human mammals characterized in that the genome of said mammals contain at least one heterologous gene encoding for the production of heterologus catalytic entity selected from the group consisting of enzymes and antibodies, and wherein said catalytic entity pr...

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Bibliographische Detailangaben
Hauptverfasser:	RICARD DALE CUMMINGS, DAVID FLETCHER SMITH, PEDRO ANTONIO PRIETO, KELLEY WILSON MOREMEN, PRADIP MUKERJI, JOHN JOSEPH KOPCHIK, JAMES MICHAEL PIERCE
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to transgenic non-human mammals characterized in that the genome of said mammals contain at least one heterologous gene encoding for the production of heterologus catalytic entity selected from the group consisting of enzymes and antibodies, and wherein said catalytic entity produces a second heterologous product in the milk of said mammal. Especially useful in the practise of the invention are human glycosyltransferases and transgenic sheep, goats and cows. The heterologous product includes oligosaccharides and glycoconjugates. La invencion se refiere a mamíferos transgénicos no humanos caracterizados porque el genoma de estos mamíferos contiene cuando menos un gen hetérologo que codifica par ala produccion de una entidad catalítica heterologa seleccionada a partir del grupo que consiste en enzimas y anticuerpos, y en donde la entidad catalítica produce un segundo producto hetérologo en la leche de dicho mamífero. Son especialmente utiles en la práctica de la invencion, las glucosiltransferasas humanas y las ovejas, cabras, y vacas transgénicas. El producto hetérologo incluye oligosacáridos y glucoconjugados.