COMPOSITIONS AND METHODS FOR STIMULATING MEGAKARYOCYTE GROWTH AND DIFFERENTIATION

Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to...

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Hauptverfasser:	JAKOB M. BOGENBERGER, TIMOTHY D. BARTLEY, OLAF B. KINSTLER, BABRU B. SAMAL, ROBERT A. BOSSELMAN, PAMELA HUNT
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water-soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans. Se describen las proteínas novedosas, denominadas como factores de crecimiento y desarrollo de megacariocitos (MGDFs; también en general denominadas como ligandos de Mp1), que tienen actividad biologica de estimulacion del crecimiento de megacariocitos y aumento de la diferenciacion o maduracion de megacariocitos, que al final dan como resultado la produccion de plaquetas. Los derivados de MGDF que comprenden moléculas de MGDF unidas a polímeros solubles en agua, tales como polietilenglicol son también descritos, junto con los métodos para su produccion. También se describen los procesos para la obtencion de los MGDFs en forma homogénea a partir de fuentes naturales, y produciéndolos mediante técnicas recombinantes de ingeniería genética a partir de mamíferos, incluyendo humanos.