QUINOLONE COMPOUND
The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkox...
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| creator | OKA, Daisuke MIYAMOTO, Hisashi YE, Fangguo SUN, Jiangqin CHENG, Jay-Fei ABUDUSAIMI, Mamuti |
| description | The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile- associated diarrhea.
La presente invención proporciona un compuesto representado por la fórmula (I) (ver Fórmula) donde X es un átomo de hidrógeno o un átomo de flúor; R es un átomo de hidrógeno o alquilo; R1 es (1) ciclopropilo sustituido en forma opcional por 1 a 3 átomos de halógeno o (2) fenilo sustituido en forma opcional por 1 a 3 átomos de halógeno; R2 es alquilo, alcoxi, haloalcoxi, un átomo de halógeno, ciano, etc.; y R3 es 7-oxo-7.8-dihidro-1.8-naftiridin ilo, 3-piridilo, etc., o una sal del mismo; el compuesto de la presente invención tiene una actividad antimicrobiana excelente contra Clostridium difficile y es útil para la prevención o tratamiento de infecciones intestinales tales como diarrea asociada a Clostridium difficile. |
| format | Patent |
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La presente invención proporciona un compuesto representado por la fórmula (I) (ver Fórmula) donde X es un átomo de hidrógeno o un átomo de flúor; R es un átomo de hidrógeno o alquilo; R1 es (1) ciclopropilo sustituido en forma opcional por 1 a 3 átomos de halógeno o (2) fenilo sustituido en forma opcional por 1 a 3 átomos de halógeno; R2 es alquilo, alcoxi, haloalcoxi, un átomo de halógeno, ciano, etc.; y R3 es 7-oxo-7.8-dihidro-1.8-naftiridin ilo, 3-piridilo, etc., o una sal del mismo; el compuesto de la presente invención tiene una actividad antimicrobiana excelente contra Clostridium difficile y es útil para la prevención o tratamiento de infecciones intestinales tales como diarrea asociada a Clostridium difficile.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200127&DB=EPODOC&CC=MX&NR=371361B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20200127&DB=EPODOC&CC=MX&NR=371361B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OKA, Daisuke</creatorcontrib><creatorcontrib>MIYAMOTO, Hisashi</creatorcontrib><creatorcontrib>YE, Fangguo</creatorcontrib><creatorcontrib>SUN, Jiangqin</creatorcontrib><creatorcontrib>CHENG, Jay-Fei</creatorcontrib><creatorcontrib>ABUDUSAIMI, Mamuti</creatorcontrib><title>QUINOLONE COMPOUND</title><description>The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile- associated diarrhea.
La presente invención proporciona un compuesto representado por la fórmula (I) (ver Fórmula) donde X es un átomo de hidrógeno o un átomo de flúor; R es un átomo de hidrógeno o alquilo; R1 es (1) ciclopropilo sustituido en forma opcional por 1 a 3 átomos de halógeno o (2) fenilo sustituido en forma opcional por 1 a 3 átomos de halógeno; R2 es alquilo, alcoxi, haloalcoxi, un átomo de halógeno, ciano, etc.; y R3 es 7-oxo-7.8-dihidro-1.8-naftiridin ilo, 3-piridilo, etc., o una sal del mismo; el compuesto de la presente invención tiene una actividad antimicrobiana excelente contra Clostridium difficile y es útil para la prevención o tratamiento de infecciones intestinales tales como diarrea asociada a Clostridium difficile.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBAKDPX08_fx93NVcPb3DfAP9XPhYWBNS8wpTuWF0twMcm6uIc4euqkF-fGpxQWJyal5qSXxvhHG5obGZoZOxgQVAACpPx0m</recordid><startdate>20200127</startdate><enddate>20200127</enddate><creator>OKA, Daisuke</creator><creator>MIYAMOTO, Hisashi</creator><creator>YE, Fangguo</creator><creator>SUN, Jiangqin</creator><creator>CHENG, Jay-Fei</creator><creator>ABUDUSAIMI, Mamuti</creator><scope>EVB</scope></search><sort><creationdate>20200127</creationdate><title>QUINOLONE COMPOUND</title><author>OKA, Daisuke ; MIYAMOTO, Hisashi ; YE, Fangguo ; SUN, Jiangqin ; CHENG, Jay-Fei ; ABUDUSAIMI, Mamuti</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX371361B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>OKA, Daisuke</creatorcontrib><creatorcontrib>MIYAMOTO, Hisashi</creatorcontrib><creatorcontrib>YE, Fangguo</creatorcontrib><creatorcontrib>SUN, Jiangqin</creatorcontrib><creatorcontrib>CHENG, Jay-Fei</creatorcontrib><creatorcontrib>ABUDUSAIMI, Mamuti</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OKA, Daisuke</au><au>MIYAMOTO, Hisashi</au><au>YE, Fangguo</au><au>SUN, Jiangqin</au><au>CHENG, Jay-Fei</au><au>ABUDUSAIMI, Mamuti</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>QUINOLONE COMPOUND</title><date>2020-01-27</date><risdate>2020</risdate><abstract>The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile- associated diarrhea.
La presente invención proporciona un compuesto representado por la fórmula (I) (ver Fórmula) donde X es un átomo de hidrógeno o un átomo de flúor; R es un átomo de hidrógeno o alquilo; R1 es (1) ciclopropilo sustituido en forma opcional por 1 a 3 átomos de halógeno o (2) fenilo sustituido en forma opcional por 1 a 3 átomos de halógeno; R2 es alquilo, alcoxi, haloalcoxi, un átomo de halógeno, ciano, etc.; y R3 es 7-oxo-7.8-dihidro-1.8-naftiridin ilo, 3-piridilo, etc., o una sal del mismo; el compuesto de la presente invención tiene una actividad antimicrobiana excelente contra Clostridium difficile y es útil para la prevención o tratamiento de infecciones intestinales tales como diarrea asociada a Clostridium difficile.</abstract><oa>free_for_read</oa></addata></record> |
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| title | QUINOLONE COMPOUND |
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