TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS

The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein. La presente invención se refiere a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	Katherine J. KAYSER-BRICKER, George P. LUKE, David S. MILLAN, Shawn E. R. SCHILLER, Kenneth W. BAIR, Goss Stryker KAUFFMAN, Matthew W. MARTIN, Torsten HERBERTZ, Adam C. TALBOT
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention relates to inhibitors of bromo and extra terminal (BET) bromodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I): wherein W, X, Y, Z, R1, R2, R5, and R8 are as described herein. La presente invención se refiere a inhibidores de bromodominios de terminal extra y bromo (BET) que son útiles para el tratamiento de cáncer, enfermedades inflamatorias, diabetes y obesidad, que tienen la formula (I): Formula (I) en donde W, X, Y, Z, R1, R2, R5 y R8 son como se describe aquí.