NOVEL CHROMONE OXIME DERIVATIVE AND ITS USE AS ALLOSTERIC MODULATOR OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention provides a novel chromone oxime derivative of formula (I), which is a modulator of nervous system receptors sensitive to glutamate and, furthermore, presents an advantageously high brain penetration upon oral administration. The invention also relates to a pharmaceutical composition containing this compound, and to its use for the treatment or prevention of conditions associated with altered glutamatergic signalling and/or functions, or conditions which can be affected by alteration of glutamate level or signalling, particularly acute and chronic neurological and/or psychiatric disorders. La presente invencion proporciona un derivado de oxima de cromona novedoso de la formula (I), que es un modulador de los receptores del sistema nervioso sensibles al glutamato y, ademas, presenta una penetracion cerebral convenientemente alta con la administracion oral. La invencion tambien se refiere a una composicion farmaceutica que contiene este compuesto, y a su uso para el tratamiento o prevencion de condiciones asociadas con la senalizacion y/o funciones glutamatergicas alteradas, o condiciones que pueden ser afectadas por la alteracion del nivel o senalizacion de glutamato, particularmente trastornos neurologicos y/o psiquiatricos agudos y cronicos. (ver formula).