STABILIZED METERED DOSE INHALER

Pharmaceutical pressurized metered dose inhalers are disclosed having improved temperature and moisture stability comprising CFC-free, ethanol-free compositions that include lactose of particle diameter larger than 1 ?m as a means of minimizing sticking to the walls and other destabilization mechani...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	JULIO CÉSAR VEGA, FERNANDO TONEGUZZO
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Pharmaceutical pressurized metered dose inhalers are disclosed having improved temperature and moisture stability comprising CFC-free, ethanol-free compositions that include lactose of particle diameter larger than 1 ?m as a means of minimizing sticking to the walls and other destabilization mechanisms activated by moisture ingress from the environment. La presente invención se refiere a inhaladores farmacéuticos presurizados de dosis medida (1DM), con mejorada estabilidad ante cambios de temperatura y humedad, que comprenden composiciones libres de CFC (clorofluorocarburos) y etanol, que incluyen lactosa en partículas de más de 1 µm de diámetro como medio para minimizar la adherencia a las paredes y otros mecanismos de desestabilización activados por el ingreso de humedad ambiental.