COMPOSITION PHARMACEUTIQUE A LIBERATION PROLONGÉE DE TRIMETAZIDINE

COMPOSITION PHARMACEUTIQUE A LIBERATION PROLONGÉE DE TRIMETAZIDINE

Composition for prolonged release of trimetazidine, comprises an inner phase comprising trimetazidine and an outer layer comprising a retardant and an antiagglomerant. An independent claim is included for preparing the composition comprising coating the neutral cores with trimetazidine and the binde...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Patrick GENTY, Jean-Manuel PEAN, Christophe HERMELIN
Format: Patent
Sprache:eng ; spa
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Composition for prolonged release of trimetazidine, comprises an inner phase comprising trimetazidine and an outer layer comprising a retardant and an antiagglomerant. An independent claim is included for preparing the composition comprising coating the neutral cores with trimetazidine and the binder to form minigranules, coating the minigranules with the retardant, the plasticizer and the antiagglomerant, and filling the coated minigranules into capsules, optionally in the presence of a lubricant. Composición de liberación prolongada de trimetazidina en la que la fase interna comprende trimetazidina y la capa externa comprende un retardante y un anti-aglomerante.