PHARMACEUTICAL COMPOSITIONS OF PACLITAXEL, PACLITAXEL ANALOGS OR PACLITAXEL CONJUGATES AND RELATED METHODS OF PREPARATION AND USE

Pharmaceutical compositions useful for hydrophobic agents paclitaxel, paclitaxel analogs and conjugates thereof (e g ANG1005) which do not contain Cremophor. The compositions further comprise an optional tonicity agent, a buffering agent a bulking agent and a solubilizmg agent which is not Cremophor...

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Hauptverfasser:	REINHARD GABATHULER, MICHEL DEMEULE, ANTHONY REGINA, RICHARD BELIVEAU, CATHERINE GAGNON, JEAN-PAUL CASTAIGNE, CHRISTIAN CHE
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Pharmaceutical compositions useful for hydrophobic agents paclitaxel, paclitaxel analogs and conjugates thereof (e g ANG1005) which do not contain Cremophor. The compositions further comprise an optional tonicity agent, a buffering agent a bulking agent and a solubilizmg agent which is not Cremophor. Methods of preparing said compositions and of said compositions in the treatment of cancer are also included. Composiciones farmacéuticas útiles para agentes hidrófobos paclitaxel, análogos de paclitaxel y conjugados de los mismos (v. gr., ANG1005) que no contienen Cremophor. Las composiciones además comprenden un agente de tonicidad opcional, un agente regulador, un agente de volumen y un agente solubilizante que no es Cremophor. Métodos para preparar dichas composiciones y de dichas composiciones en el tratamiento de cáncer también se incluyen.