METHOD FOR THE SYNTHESIS OF DERIVATIVES OF 7,8-DIMETHOXY-1,3-DIHY DRO-2H-3-BENZAZEPIN-2-ONE AND APPLICATION TO THE SYNTHESIS OF IVABRADINE

METHOD FOR THE SYNTHESIS OF DERIVATIVES OF 7,8-DIMETHOXY-1,3-DIHY DRO-2H-3-BENZAZEPIN-2-ONE AND APPLICATION TO THE SYNTHESIS OF IVABRADINE

The invention relates to a method for the synthesis of the compound of formula (I) wherein R is a paramethoxybenzyl (PMB) group or the group corresponding to formula (II). The invention also relates to the application of the method to the synthesis of ivabradine and the pharmaceutically acceptable a...

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Bibliographische Detailangaben
1. Verfasser: Alexandre LE FLOHIC
Format: Patent
Sprache:eng ; spa
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to a method for the synthesis of the compound of formula (I) wherein R is a paramethoxybenzyl (PMB) group or the group corresponding to formula (II). The invention also relates to the application of the method to the synthesis of ivabradine and the pharmaceutically acceptable acid addition salts thereof. Procedimiento de síntesis del compuesto de fórmula (I): (ver Fórmula) en la que R representa un grupo para-metoxibencilo (PMB) o el grupo siguiente: (ver Fórmula) Aplicación a la síntesis de la ivabradina y de sus sales de adición a un ácido farmacéuticamente aceptable.