PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER

The present invention provides MDM2 inhibitor compounds of Formula (I), wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibit...

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Bibliographische Detailangaben
Hauptverfasser:	Zhihua MA, John EKSTEROWICZ, Jeffret Thomas MIHALIC, Jiang ZHU, Jonathan Dante LOW, Jason DUQUETTE, Jiasheng FU, Ana GONZÁLEZ BUENROSTRO, Felix GONZÁLEZ LÓPEZ DE TURISO, Yingeai WANG, Zhihong LI, Xianyun JIAO, Richard Victor CONNORS, Michael William GRIBBLE JR, Darin James GUSTIN, Zice FU, Dustin MCMINN, Xiaoqi CHEN, Michael JOHNSON, Philip Marley ROVETO, Yihong LI, Julie Anne HEATH, Steven Howard OLSON, Jiwen LIU, Yosup REW, Daqing SUN, Sujen LAI, Joel MCINTOSH, Benjamin FISHER, Xin HUANG, Hilary Plake BECK, Frank KAYSER, Xuelei YAN, Xiaodong WANG, Michael David BARTBERGER, David John KOPECKY, Lawrence MCGEE, Jeffery DEIGNAN, Ming YU, Brian Matthew FOX, Brian Stuart LUCAS, Julio Cesar MEDINA
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:	The present invention provides MDM2 inhibitor compounds of Formula (I), wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor. La presente invención proporciona compuestos de inhibidor MDM2 de la Fórmula I, (ver Fórmula) en donde las variables se definen arriba, cuyos compuestos son útiles como agentes terapéuticos, particularmente para el tratamiento de cánceres. La presente invención también se refiere a composiciones farmacéuticas que contienen un inhibidor MDM2.