SERINE/THREONINE KINASE INHIBITORS
Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders. Compuestos que tienen la fórmula I, en donde: (Ver Formula) en donde Z, z1 z2 z3, R3a, R3b y...
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| creator | WENGLOWSKY, Steven Mark CHEN, Huifen BLAKE, James F MOHR, Peter J KAUS, Robert J KOLAKOWSKI, Gabrielle R WALLACE, Eli GARREY, Rustam SIEDEM, Christopher S GUADINO, John J MARLOW, Allison L DEMEESE, Jason CHICARELLI, Mark Joseph REN, Li THOMAS, Allen A SCHWARZ, Jacob |
| description | Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
Compuestos que tienen la fórmula I, en donde: (Ver Formula) en donde Z, z1 z2 z3, R3a, R3b y Rb y como se define en la presente son inhibidores de ERK cinasa. También se describen composiciones y métodos para tratar trastornos hiperproliferativos. |
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Compuestos que tienen la fórmula I, en donde: (Ver Formula) en donde Z, z1 z2 z3, R3a, R3b y Rb y como se define en la presente son inhibidores de ERK cinasa. También se describen composiciones y métodos para tratar trastornos hiperproliferativos.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2016</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160615&DB=EPODOC&CC=MX&NR=339873B$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20160615&DB=EPODOC&CC=MX&NR=339873B$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WENGLOWSKY, Steven Mark</creatorcontrib><creatorcontrib>CHEN, Huifen</creatorcontrib><creatorcontrib>BLAKE, James F</creatorcontrib><creatorcontrib>MOHR, Peter J</creatorcontrib><creatorcontrib>KAUS, Robert J</creatorcontrib><creatorcontrib>KOLAKOWSKI, Gabrielle R</creatorcontrib><creatorcontrib>WALLACE, Eli</creatorcontrib><creatorcontrib>GARREY, Rustam</creatorcontrib><creatorcontrib>SIEDEM, Christopher S</creatorcontrib><creatorcontrib>GUADINO, John J</creatorcontrib><creatorcontrib>MARLOW, Allison L</creatorcontrib><creatorcontrib>DEMEESE, Jason</creatorcontrib><creatorcontrib>CHICARELLI, Mark Joseph</creatorcontrib><creatorcontrib>REN, Li</creatorcontrib><creatorcontrib>THOMAS, Allen A</creatorcontrib><creatorcontrib>SCHWARZ, Jacob</creatorcontrib><title>SERINE/THREONINE KINASE INHIBITORS</title><description>Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
Compuestos que tienen la fórmula I, en donde: (Ver Formula) en donde Z, z1 z2 z3, R3a, R3b y Rb y como se define en la presente son inhibidores de ERK cinasa. También se describen composiciones y métodos para tratar trastornos hiperproliferativos.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2016</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFAKdg3y9HPVD_EIcvX3A7IUvD39HINdFTz9PDydPEP8g4J5GFjTEnOKU3mhNDeDnJtriLOHbmpBfnxqcUFicmpeakm8b4SxsaWFubGTMUEFAI3aIaY</recordid><startdate>20160615</startdate><enddate>20160615</enddate><creator>WENGLOWSKY, Steven Mark</creator><creator>CHEN, Huifen</creator><creator>BLAKE, James F</creator><creator>MOHR, Peter J</creator><creator>KAUS, Robert J</creator><creator>KOLAKOWSKI, Gabrielle R</creator><creator>WALLACE, Eli</creator><creator>GARREY, Rustam</creator><creator>SIEDEM, Christopher S</creator><creator>GUADINO, John J</creator><creator>MARLOW, Allison L</creator><creator>DEMEESE, Jason</creator><creator>CHICARELLI, Mark Joseph</creator><creator>REN, Li</creator><creator>THOMAS, Allen A</creator><creator>SCHWARZ, Jacob</creator><scope>EVB</scope></search><sort><creationdate>20160615</creationdate><title>SERINE/THREONINE KINASE INHIBITORS</title><author>WENGLOWSKY, Steven Mark ; CHEN, Huifen ; BLAKE, James F ; MOHR, Peter J ; KAUS, Robert J ; KOLAKOWSKI, Gabrielle R ; WALLACE, Eli ; GARREY, Rustam ; SIEDEM, Christopher S ; GUADINO, John J ; MARLOW, Allison L ; DEMEESE, Jason ; CHICARELLI, Mark Joseph ; REN, Li ; THOMAS, Allen A ; SCHWARZ, Jacob</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX339873B3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2016</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>WENGLOWSKY, Steven Mark</creatorcontrib><creatorcontrib>CHEN, Huifen</creatorcontrib><creatorcontrib>BLAKE, James F</creatorcontrib><creatorcontrib>MOHR, Peter J</creatorcontrib><creatorcontrib>KAUS, Robert J</creatorcontrib><creatorcontrib>KOLAKOWSKI, Gabrielle R</creatorcontrib><creatorcontrib>WALLACE, Eli</creatorcontrib><creatorcontrib>GARREY, Rustam</creatorcontrib><creatorcontrib>SIEDEM, Christopher S</creatorcontrib><creatorcontrib>GUADINO, John J</creatorcontrib><creatorcontrib>MARLOW, Allison L</creatorcontrib><creatorcontrib>DEMEESE, Jason</creatorcontrib><creatorcontrib>CHICARELLI, Mark Joseph</creatorcontrib><creatorcontrib>REN, Li</creatorcontrib><creatorcontrib>THOMAS, Allen A</creatorcontrib><creatorcontrib>SCHWARZ, Jacob</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WENGLOWSKY, Steven Mark</au><au>CHEN, Huifen</au><au>BLAKE, James F</au><au>MOHR, Peter J</au><au>KAUS, Robert J</au><au>KOLAKOWSKI, Gabrielle R</au><au>WALLACE, Eli</au><au>GARREY, Rustam</au><au>SIEDEM, Christopher S</au><au>GUADINO, John J</au><au>MARLOW, Allison L</au><au>DEMEESE, Jason</au><au>CHICARELLI, Mark Joseph</au><au>REN, Li</au><au>THOMAS, Allen A</au><au>SCHWARZ, Jacob</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SERINE/THREONINE KINASE INHIBITORS</title><date>2016-06-15</date><risdate>2016</risdate><abstract>Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
Compuestos que tienen la fórmula I, en donde: (Ver Formula) en donde Z, z1 z2 z3, R3a, R3b y Rb y como se define en la presente son inhibidores de ERK cinasa. También se describen composiciones y métodos para tratar trastornos hiperproliferativos.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SERINE/THREONINE KINASE INHIBITORS |
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