SERINE/THREONINE KINASE INHIBITORS

Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders. Compuestos que tienen la fórmula I, en donde: (Ver Formula) en donde Z, z1 z2 z3, R3a, R3b y...

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Bibliographische Detailangaben
Hauptverfasser:	WENGLOWSKY, Steven Mark, CHEN, Huifen, BLAKE, James F, MOHR, Peter J, KAUS, Robert J, KOLAKOWSKI, Gabrielle R, WALLACE, Eli, GARREY, Rustam, SIEDEM, Christopher S, GUADINO, John J, MARLOW, Allison L, DEMEESE, Jason, CHICARELLI, Mark Joseph, REN, Li, THOMAS, Allen A, SCHWARZ, Jacob
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders. Compuestos que tienen la fórmula I, en donde: (Ver Formula) en donde Z, z1 z2 z3, R3a, R3b y Rb y como se define en la presente son inhibidores de ERK cinasa. También se describen composiciones y métodos para tratar trastornos hiperproliferativos.