PYRIMIDINES FOR DEGRADING BRUTON'S TYROSINE KINASE

The present invention provides for compounds of formula (I), wherein R1, R2, R3, R4A, R4b, and R5, are as defined herein, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL. La presente invención proporciona compuestos de la Fórmula (I) (ver Fórmula) (I)...

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Bibliographische Detailangaben
Hauptverfasser:	ADAMS Ashley M, BIANNIC Berenger, ZHAO Xianrui, RIVKIN Alexey A, JIA Zhaozhong J, ZABLOCKI Jeffery A, MARIN Violeta L, BURKE Jason P, MORTEZAEI Shahab, OKANO Akinori, BIAN Zhiguo, WOLLER Kevin R, KATCHER Matthew H, MALI Venkat Reddy, PAYETTE Joshua N, SCHOLZ Spencer O, NOEY Elizabeth L, JIANG Xingyu
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides for compounds of formula (I), wherein R1, R2, R3, R4A, R4b, and R5, are as defined herein, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL. La presente invención proporciona compuestos de la Fórmula (I) (ver Fórmula) (I); en donde R1, R2, R3, R4A, R4b, y R5, son como se definen en la presente descripción, y sales farmacéuticamente aceptables de estos, que son útiles como agentes en el tratamiento de la CLL.