CAS12A NICKASES

The present invention relates to the field of gene genome editing. In particular, it relates to the provision of a Cas12a enzyme having nickase activity, as well as the means and methods for the modification of a genomic locus of interest with a Cas12a enzyme having nickase activity and uses thereof...

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Bibliographische Detailangaben
Hauptverfasser:	LUTEIJN Maartje Janneke, WU Wen Ying, KATELIJN D''halluin, MEULEWAETER Frank, STAALS Raymond Hubert Josèphe, VAN DER OOST John, VILLEGAS WARREN Ricardo, DE VLEESSCHAUWER David
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to the field of gene genome editing. In particular, it relates to the provision of a Cas12a enzyme having nickase activity, as well as the means and methods for the modification of a genomic locus of interest with a Cas12a enzyme having nickase activity and uses thereof. La presente invención se refiere al campo de la edición del genoma génico. En particular, se refiere a la provisión de una enzima Cas12a que tiene actividad de nickasa, así como también a los medios y métodos para la modificación de un locus genómico de interés con una enzima Cas12a que tiene actividad de nickasa y usos de estos.