SYNTHESIS OF BRUTON'S TYROSINE KINASE INHIBITORS

SYNTHESIS OF BRUTON'S TYROSINE KINASE INHIBITORS

The present disclosure is directed to methods of synthesizing a compound of Formula (I), where the R groups are defined herein, and to methods of synthesizing a compound of Formula (II). Some aspects of the present disclosure is directed to converting the compound of Formula (II) into its P form. La...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: XIOURAS Christos, RAMMELOO Thomas Joachim Landewald, CLEATOR Edward, MATON William Marc, FERNANDES Philippe, TRAN Ngoc Duc
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure is directed to methods of synthesizing a compound of Formula (I), where the R groups are defined herein, and to methods of synthesizing a compound of Formula (II). Some aspects of the present disclosure is directed to converting the compound of Formula (II) into its P form. La presente descripción se dirige a métodos para sintetizar un compuesto de la Fórmula (I), donde los grupos R se definen en la presente descripción, y (ver Fórmula) a métodos para sintetizar un compuesto de la Fórmula (II): (ver Fórmula) Algunos aspectos de la presente descripción se dirigen a convertir el compuesto de la Fórmula (II) en su forma P.