FULLY HUMAN ANTIBODY TARGETING GPRC5D AND CHIMERIC ANTIGEN RECEPTOR (CAR) AND USE THEREOF

A fully human antibody targeting GPRC5D and a chimeric antigen receptor (CAR) comprising the fully human antibody. A host cell expressing the CAR, such as a CAR-T cell. A use of the fully human antibody, the CAR, and the CAR-T cell in treatment of tumors (such as multiple myeloma). La presente inven...

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Bibliographische Detailangaben
Hauptverfasser:	ZHAO Ya, ZHANG Qianqian, LUO Qian, WEI Qiaoe, LIU Jianwei, ZHANG Yanying, TAN Taochao, DAI Zhenyu, JIA Xiangyin, XIE Meng
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A fully human antibody targeting GPRC5D and a chimeric antigen receptor (CAR) comprising the fully human antibody. A host cell expressing the CAR, such as a CAR-T cell. A use of the fully human antibody, the CAR, and the CAR-T cell in treatment of tumors (such as multiple myeloma). La presente invención proporciona un anticuerpo completamente humanizado dirigido a GPRC5D y un receptor de antígeno quimérico (CAR) que comprende el anticuerpo completamente humanizado. La presente invención también proporciona una célula hospedera que expresa el CAR, tal como una célula CAR-T. La presente invención también proporciona el uso del anticuerpo completamente humanizado, el CAR y la célula CAR-T en el tratamiento de tumores (por ejemplo, mieloma múltiple).