FUSION PROTEINS COMPRISING ALPHA-L-IDURONIDASE ENZYMES AND METHODS

Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise an alpha-L-iduronidase (IDUA) enzyme-Fc fusion polypeptide. Certain embodiments also provide methods of using such proteins to treat MPS I. En el presente documento se proporcionan...

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Bibliographische Detailangaben
Hauptverfasser:	MAHON Cathal S, YAMANOKUCHI Kensuke, KARIOLIS Mihalis S, TYAGI Shrishti, ADUSUMILLI Gowrisudha, DAVIS Oliver Brayer
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise an alpha-L-iduronidase (IDUA) enzyme-Fc fusion polypeptide. Certain embodiments also provide methods of using such proteins to treat MPS I. En el presente documento se proporcionan proteínas, que son capaces de ser transportadas a través de la barrera hematoencefálica (BBB) y comprenden un polipéptido de fusión Fc-enzima alfa-L-iduronidasa (IDUA). Ciertas modalidades también proporcionan métodos para usar tales proteínas para tratar MPS I.