DISCERNIBLE CELL SURFACE PROTEIN VARIANTS OF CD45 FOR USE IN CELL THERAPY

The present disclosure relates to the use of cells having discernible surface protein with engineered or naturally occurring mutation(s) but functional surface protein for use in therapy. The present invention also relates to the use of cells having discernible CD45 surface protein variants but func...

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Bibliographische Detailangaben
Hauptverfasser: URLINGER Stefanie, DEVAUX Anna, LEPORE Rosalba, HAYDN Anna, MATTER MARONE Romina, DURZYNSKA Izabela, CAMUS Anna, GARAUDE Simon, JEKER Lukas, SINOPOLI Alessandro
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:The present disclosure relates to the use of cells having discernible surface protein with engineered or naturally occurring mutation(s) but functional surface protein for use in therapy. The present invention also relates to the use of cells having discernible CD45 surface protein variants but functional surface protein for use in therapy, in particular adoptive cell therapy. La presente divulgación se refiere al uso de células que tienen proteína de superficie discernible con mutación(es) diseñada(s) o de origen natural, pero proteína de superficie funcional para usarse en terapia. La presente invención también se refiere al uso de células que tienen variantes discernibles de proteína de superficie CD45, pero proteína de superficie funcional para usarse en terapia, en particular en terapia celular adoptiva.