COMPOUNDS

COMPOUNDS

Compounds of formula (I) wherein Y, n, R1, R2 and R3 have the meanings indicated herein, or a pharmaceutically acceptable solvate or salt thereof, are disclosed. The compounds are useful as inhibitors of protein or lipid kinases (in particular as inhibitors of a member of the PIM family of kinases,...

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Bibliographische Detailangaben
Hauptverfasser: Rosa María ÁLVAREZ ESCOBAR, GONZÁLEZ CANTALAPIEDRA Esther, CEBRIÁN MUÑOZ David Álvaro, HERNÁNDEZ ENCINAS Elena, FERNÁNDEZ Joaquin Pastor, MARTÍN HERNANDO Jose Ignacio, ALBARRÁN SANTIÑO María Isabel, RAMOS LIMA Francisco Javier, BLANCO APARICIO Carmen, GARCÍA GARCÍA Ana Belén, GÓMEZ DE LA OLIVA Cristina Ana, RIESCO FAGUNDO Rosario Concepción, MARTÍNEZ GONZÁLEZ Sonia, CEBRIÁ GÓMEZ Antonio
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compounds of formula (I) wherein Y, n, R1, R2 and R3 have the meanings indicated herein, or a pharmaceutically acceptable solvate or salt thereof, are disclosed. The compounds are useful as inhibitors of protein or lipid kinases (in particular as inhibitors of a member of the PIM family of kinases, e.g. PIM-1, PIM-2 or PIM-3) and can be used in the treatment of a number of conditions, in particular cancers. Se describen compuestos de fórmula I: (ver Fórmula) en donde Y, n, R1, R2 y R3 tienen los significados indicados en la presente, o un solvato o sal farmacéuticamente aceptable de los mismos; los compuestos son útiles como inhibidores de proteínas o lípidos cinasas (en particular como inhibidores de un miembro de la familia de las cinasas PIM, por ejemplo, PIM-1, PIM-2 o PIM-3), y pueden usarse en el tratamiento de una serie de enfermedades, en particular cánceres.