NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF

The present invention provides a new class of non-immunosupressive FK506 analogs which are FKBP-selective, small-molecule BMP agonists with modest potency therepeutics for tissue repair and regeneration. Also disclosed herein are methods for making and use of these compounds. La presente invención p...

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Bibliographische Detailangaben
Hauptverfasser:	WANG Yuefan, LIU Jun O, PENG Hanjing, AHMADI Ali, GUO Zufeng, PEIFFER Brandon J, QI Le, SUN Zhaoli
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The present invention provides a new class of non-immunosupressive FK506 analogs which are FKBP-selective, small-molecule BMP agonists with modest potency therepeutics for tissue repair and regeneration. Also disclosed herein are methods for making and use of these compounds. La presente invención proporciona una nueva clase de análogos de FK506 no inmunosupresores que son agonistas de BMP selectivos de FKBP, de molécula pequeña, con potencia terapéutica modesta para la reparación y regeneración de tejidos. También se describen en la presente métodos para elaborar y utilizar estos compuestos.