METHOD FOR PRODUCING 7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AND SYNTHETIC INTERMEDIATE OF SAME

The purpose of the present invention is to provide: a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative which is useful as a Janus kinase (JAK) inhibitory agent; an intermediate of the same; and a method for producing the intermediate. Provided is a method for producing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-1,6-Di azaspiro[3.4]octane-1-yl]-3-oxopropanenitrile using an organic acid of (3S,4R)-1-benzyl-3-methyl-1,6-Diazaspiro[3.4]octane and a salt thereof. La presente invención proporciona procesos para preparar derivados de 7H-pirrolo[2,3-d]pirimidina, que son útiles como un inhibidor de Janus quinasa (JAK), intermedios de los mismos, y procesos para preparar los intermedios; la presente invención proporciona procesos para preparar 3-[(3S,4R)-3-metil-6-(7H-pirrol o[2,3-d]pirimidin-4-il)-1,6-diazaespiro[3.4]octan-1-il]-3- oxopropanonitrilo usando sales de (3S,4R)-1-bencil-3-metil-1,6-dia zaespiro[3.4]octano con ácidos orgánicos.