FORMULATIONS OF FACTOR VIII CHIMERIC PROTEINS AND USES THEREOF

FORMULATIONS OF FACTOR VIII CHIMERIC PROTEINS AND USES THEREOF

The present disclosure provides pharmaceutical compositions of a chimeric protein comprising a factor VIII (FVIII) polypeptide and a von Willebrand factor (VWF) polypeptide. Also disclosed are pharmaceutical kits and methods of using the disclosed pharmaceutical compositions to treat hemophilia A. L...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MAULDIN Randall, MCCOY Timothy R, TAZI Loubna Mzaalak, CARLAGE Tyler
Format: Patent
Sprache:eng ; spa
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present disclosure provides pharmaceutical compositions of a chimeric protein comprising a factor VIII (FVIII) polypeptide and a von Willebrand factor (VWF) polypeptide. Also disclosed are pharmaceutical kits and methods of using the disclosed pharmaceutical compositions to treat hemophilia A. La presente divulgación proporciona composiciones farmacéuticas de una proteína quimérica que comprende un polipéptido de factor VIII (FVIII) y un polipéptido de factor de von Willebrand (VWF). También se divulgan kits farmacéuticos y métodos de uso de las composiciones farmacéuticas divulgadas para tratar la hemofilia A.