PARG INHIBITORY COMPOUNDS

The present invention relates to a compound of formula (I) or an enantiomer, diastereoisomer, tautomer, pharmaceutically acceptable solvate, pharmaceutically acceptable crystal form, pharmaceutically acceptable salt or a prodrug thereof. The present invention further relates to the compound of formu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	LUECKING Ulrich, IACOVINO Luca, SOTIRIOU Sotirios, QUEROLLE Olivier, TIAN Jin, GOUTOPOULOS Andreas, FREUDENMANN Alena
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a compound of formula (I) or an enantiomer, diastereoisomer, tautomer, pharmaceutically acceptable solvate, pharmaceutically acceptable crystal form, pharmaceutically acceptable salt or a prodrug thereof. The present invention further relates to the compound of formula (I) of the present invention for use in therapy. Instant compounds are particularly useful as PARC inhibitors, and can be used in a method of treatment of a proliferative disorder, preferably of cancer. La presente invención se relaciona con un compuesto de la Fórmula (I) o un enantiómero, diastereoisómero, tautómero, solvato farmacéuticamente aceptable, forma cristalina farmacéuticamente aceptable, sal farmacéuticamente aceptable o un profármaco de este. La presente invención se relaciona además con el compuesto de la Fórmula (I) de la presente invención para usar en terapia. Los compuestos instantáneos son particularmente útiles como inhibidores de PARC, y se pueden usar en un método de tratamiento de un trastorno proliferativo, preferentemente de cáncer.