PYRROLO BENZODIAZEPINE DERIVATIVE, AND CONJUGATE, PREPARATION METHOD AND USE THEREOF

The present disclosure relates to a pyrrolo benzodiazepine derivative and a conjugate, preparation method and use thereof. In particular, the present disclosure relates to a compound of formula (DL) and a antibody-drug conjugate thereof, a pharmaceutical composition containing same, and a use thereo...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG Ying, YOU Lingfeng, LI Yanbing, HONG Min, HUANG Jian, HU Zhipeng, XU Jianyan, TAO Weikang, QU Bolei, CHEN Xiaoxi, XU Xiaolang, CAI Xiaofeng, ZHU Lingjian, HE Feng, XUE Zhouyang
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure relates to a pyrrolo benzodiazepine derivative and a conjugate, preparation method and use thereof. In particular, the present disclosure relates to a compound of formula (DL) and a antibody-drug conjugate thereof, a pharmaceutical composition containing same, and a use thereof in the preparation of a medicament for the treatment of cancer. The definitions of groups in the general formula (DL) are as defined in the description. La presente invención se refiere a un derivado de pirrolo benzodiazepina y un conjugado, método de preparación y uso del mismo. En particular, la presente invención se refiere a un compuesto de fórmula (DL) y su conjugado anticuerpo-fármaco, una composición farmacéutica que lo contiene y su uso en la preparación de un medicamento para el tratamiento del cáncer. Las definiciones de grupos en la fórmula general (DL) son las definidas en la descripción. (ver Fórmula).