PYRIDINE DERIVATIVE AND USE THEREOF

A pyridine derivative and use thereof. The compound has an obvious inhibitory effect on the activity of KRAS and PI3K proteins, can be used as a KRAS and/or PI3K protein inhibitor, and can be used for preparing a drug for treatment of diseases such as KRAS or PI3K protein-mediated cancer. The compou...

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Bibliographische Detailangaben
Hauptverfasser:	CHEN Shoujun, QIANG Xiaoming, XIONG Yong, WANG Haibo, LIU Mingdeng, LIU Ke, DING Zhao
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A pyridine derivative and use thereof. The compound has an obvious inhibitory effect on the activity of KRAS and PI3K proteins, can be used as a KRAS and/or PI3K protein inhibitor, and can be used for preparing a drug for treatment of diseases such as KRAS or PI3K protein-mediated cancer. The compound has an extremely strong inhibitory effect on a KRAS G12C inhibitor drug-resistant cancer cell, e.g. AMG-510, and has a wide application prospect. Un derivado de piridina y su uso. El compuesto tiene un efecto inhibidor obvio sobre la actividad de las proteínas KRAS y PI3K, se puede utilizar como inhibidor de la proteína KRAS y/o PI3K, y se puede utilizar para preparar un fármaco para el tratamiento de enfermedades tales como el cáncer mediado por la proteína KRAS o PI3K. El compuesto tiene un efecto inhibidor extremadamente fuerte sobre las células cancerosas resistentes a los fármacos inhibidores de KRAS G12C (por ejemplo, AMG-510), y tiene una amplia perspectiva de aplicación del mismo.