TETRAZOLE COMPOUNDS WITH ANTI-INFLAMMATORY ACTIVITY

The present invention relates to compounds that are derivatives of Imatinib, have a phenylamino pyrimidine group and another 1,5-disubstituted tetrazole group within their structure, and have anti-inflammatory activity. Also, it relates to pharmaceutical compositions comprising said compounds and to...

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Bibliographische Detailangaben
Hauptverfasser:	BAIZABAL AGUIRRE Víctor Manuel, ROMERO DURÁN Marco Antonio, CORTÉS GARCÍA Carlos Jesús
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds that are derivatives of Imatinib, have a phenylamino pyrimidine group and another 1,5-disubstituted tetrazole group within their structure, and have anti-inflammatory activity. Also, it relates to pharmaceutical compositions comprising said compounds and to a method for resolving the activation of inflammation in the Keap1-Nrf2 antioxidant-anti-inflammatory system. La presente invención se refiere a compuestos que son derivados de Imatinib y que tienen dentro de su estructura un grupo fenilaminopirimidina y otro grupo tetrazol 1,5-disustituido y que además tienen actividad antiinflamatoria. La presente invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos. Asimismo, la presente invención se refiere a un método para resolver la activación de la inflamación en el sistema antioxidante-antiinflamatorio Keap1-Nrf2.