SUBCUTANEOUS FORMULATIONS OF ANTI-ABETA PROTOFIBRIL ANTIBODY AND METHODS OF USE THEREOF

Disclosed herein are methods of treating Alzheimer's disease, methods of reducing clinical decline in a subject having early Alzheimer's disease, methods of reducing brain amyloid level in a subject, methods of converting a subject from amyloid positive to amyloid negative, methods of prev...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SACHDEV Pallavi, KOYAMA Akihiko, KANEKIYO Michio, VERBEL David, HAYATO Seiichi, DHADDA Shobha, REYDERMAN Larisa, GORDON Robert, KRAMER Lynn, IRIZARRY Michael, KAPLOW June, SWANSON Chad, LANDRY Ishani
Format: Patent
Sprache:eng ; spa
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Disclosed herein are methods of treating Alzheimer's disease, methods of reducing clinical decline in a subject having early Alzheimer's disease, methods of reducing brain amyloid level in a subject, methods of converting a subject from amyloid positive to amyloid negative, methods of preventing Alzheimer's disease, the methods comprising subcutaneously administering an anti-Aβ protofibril antibody. En el presente documento, se describen métodos para tratar la enfermedad de Alzheimer, métodos para reducir el deterioro clínico en un sujeto que tiene enfermedad de Alzheimer temprana, métodos para reducir el nivel de amiloide cerebral en un sujeto, métodos para convertir un sujeto de amiloide positivo en amiloide negativo, métodos para prevenir la enfermedad de Alzheimer, comprendiendo los métodos administrar por vía subcutánea un anticuerpo anti protofibrillas Aß.