MODIFIED GUIDE RNAS

This disclosure relates to modified single and dual guide RNAs having improved in vitro and in vivo activity in gene editing methods.This disclosure relates to modified single and dual guide RNAs having improved in vitro and in vivo activity in gene editing methods. Described herein are lipid nanopa...

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Bibliographische Detailangaben
Hauptverfasser:	SMITH Amy Madison Rhoden, MORRISSEY David V, STRAPPS Walter
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	This disclosure relates to modified single and dual guide RNAs having improved in vitro and in vivo activity in gene editing methods.This disclosure relates to modified single and dual guide RNAs having improved in vitro and in vivo activity in gene editing methods. Described herein are lipid nanoparticles comprising cationic lipids and other lipids and also comprising engineered nucleases facilitate transfer of nucleic acids to cells. Esta descripción se refiere al ARN guía único y dual modificados que tienen mejor actividad in vitro e in vivo en los métodos de edición génica.