MULTISPECIFIC BINDING AGENTS AGAINST CD40 AND CD137 IN COMBINATION THERAPY FOR CANCER

The present invention relates to combination therapy using a binding agent that binds to human CD40 and to human CD137 in combination with a checkpoint inhibitor to reduce or prevent progression of a tumor or treating cancer. La presente invención se refiere a terapia de combinación usando un agente...

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Hauptverfasser:	BREIJ Esther Cornelia Wilhelmina, GUELEN Lars, BAJAJ Gaurav, NEIJSSEN Jost, KUZMANOV Ivan, MUIK Alexander, HIBBERT Richard, FELLERMEIER-KOPF Sina, PAULMANN Claudia, III ADAMS Homer, LABRIJN Aran Frank, SAHIN Ugur, FU Yali, GIESEKE Friederike, NIEWOOD Michelle, SCHUURMAN Janine, BECKMANN Karsten, HIGGS Brandon, DE KREUK Bart - Jan, GARRIDO CASTRO Patricia, FERESHTEH Mark, SPIRES Vanessa, BLUM Jordan
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to combination therapy using a binding agent that binds to human CD40 and to human CD137 in combination with a checkpoint inhibitor to reduce or prevent progression of a tumor or treating cancer. La presente invención se refiere a terapia de combinación usando un agente de unión que se une a CD40 humano y a CD137 humano en combinación con un inhibidor de punto de control para reducir o prevenir la progresión de un tumor o tratar cáncer.