PROCESSES FOR THE PREPARATION OF (S)-2-(2,6-DIOXOPIPERIDIN-3-YL)- 4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL) METHYL)BENZYL) AMINO)ISOINDOLINE-1,3-DIONE

PROCESSES FOR THE PREPARATION OF (S)-2-(2,6-DIOXOPIPERIDIN-3-YL)- 4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL) METHYL)BENZYL) AMINO)ISOINDOLINE-1,3-DIONE

Provided herein are processes for the preparation of (S)-2-(2,6- dioxopipelidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-l-yl) methyl) benzyl)amino)isoindoline-l, 3-dione, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof, which is useful for treating, preve...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: EMMANUEL Megan, CHEN Jian, KASSIM Amude, DUNN Robert Francis, CARRASQUILLO-FLORES Ronald, TAVARES-GRECO Paula A, YU Yong, FERRETTI Antonio C, ZHANG Chengmin, CORONA Patrick, LIU Wei, DEL VALLE David, PURDUM Geoffrey Eugene, YONG Kelvin Hin-yeong, KOTHARE Mohit, HEID Richard Martin, RANGANATHAN Krishnakumar
Format: Patent
Sprache:eng ; spa
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Provided herein are processes for the preparation of (S)-2-(2,6- dioxopipelidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-l-yl) methyl) benzyl)amino)isoindoline-l, 3-dione, or a salt, solvate, hydrate, enantiomer, mixture of enantiomers, or isotopologue thereof, which is useful for treating, preventing, and managing various disorders. Also provided are solid forms of various intermediates and products obtained from the processes. En el presente documento se proporcionan procesos para la preparación de (S)-2-(2,6-dioxopiperidin-3-il)-4-((2-fluoro-4-((3- morfolinoazetidin-1-il)metil)bencil)amino)isoindolin-1,3-diona, o una sal, solvato, hidrato, enantiómero, mezcla de enantiómeros o isotopólogo de la misma, que es útil para tratar, prevenir y gestionar diversos trastornos. También se proporcionan formas sólidas de diversos intermediarios y productos que se obtienen a partir de los procesos.