RECOMBINANT TERT-ENCODING VIRAL GENOMES AND VECTORS

Described herein are recombinant viral genomes comprising a nucleotide sequence encoding a telomerase reverse transcriptase (TERT) operably linked to a tissue-specific and/or organ-specific promoter. Aspects described herein may be used in the treatment of conditions associated with shortened telome...

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Hauptverfasser:	JIMENEZ CENZANO Verónica, Fàtima BOSCH TUBERT Maria, MARTINEZ Paula, GARCIA MARTINEZ Miquel, BLASCO María, CASANA LORENTE Estefanía
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Described herein are recombinant viral genomes comprising a nucleotide sequence encoding a telomerase reverse transcriptase (TERT) operably linked to a tissue-specific and/or organ-specific promoter. Aspects described herein may be used in the treatment of conditions associated with shortened telomere length, such as pulmonary fibrosis, myocardial infarction and conditions associated therewith. Se describen en el presente documento genomas virales que comprenden una secuencia de nucleótidos que codifica una telomerasa transcriptasa inversa (TERT) unida operativamente a un promotor específico de tejido y/o específico de órgano. Los aspectos descritos en el presente documento pueden usarse en el tratamiento de afecciones asociadas con una longitud de telómeros acortada, tales como fibrosis pulmonar, infarto de miocardio y afecciones asociadas con los mismos.