PROCESS FOR PREPARING BTK INHIBITORS

PROCESS FOR PREPARING BTK INHIBITORS

Methods for preparing the Bruton's Tyrosine Kinase ("BTK") inhibitor compound 2-{3'-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-p iperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4']bipyri dinyl-2'-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4...

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Bibliographische Detailangaben
Hauptverfasser: CHYTIL Lukas, FANTASIA Serena Maria, TOSATTI Paolo, BACHMANN Stephan, KAPPE Christian Oliver, FETTES Alec, LEBL Rene, PUENTENER Kurt, WILLIAMS Jason Douglas, HOFFMANN Ursula
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Methods for preparing the Bruton's Tyrosine Kinase ("BTK") inhibitor compound 2-{3'-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-p iperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4']bipyri dinyl-2'-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4, 5]pyrrolo[1,2-a]pyrazin-1-one are provided. Se proporcionan métodos para preparar el compuesto inhibidor de la tirosina quinasa de Bruton ("BTK") 2-{3'-hidroximetil-1-metil-5 -[5-((S)-2-metil-4-oxetan-3-il-piperazin-1-il)-piridin-2-ilamino] -6-oxo-1,6-dihidro-[3,4']bipiridinil-2'-il}-7,7-dimetil-3,4,7,8-t etrahidro-2H,6H-ciclopenta[4,5]pirrolo[1,2-a]pirazin-1-ona.