ANTIBODY DRUG CONJUGATES AND METHODS FOR MAKING THEREOF

This application discloses microorganisms and methods of producing GNAQ/GNA11 inhibitors and methods of making antibody drug conjugates of anti-PMEL17 antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The disclosure also relates to formulations comprising antibody drug co...

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Hauptverfasser:	MANCHADO ROBLES Eusebio, FESSLER Boris, IYER Shwetha, BUNTIN Kathrin, HAINZL Dominik, ROMANET Vincent, BLUEMMEL Anne - Sophie, FAN Liqiong, YERRAMILLI-RAO Padmaja, WUERSCH Kuno, KHERA Eshita, MAUDENS Pierre, D''ALESSIO Joseph Anthony, RAMOT Roee, PISTORIUS Dominik, GABRIEL Doris, HOFFMASTER Keith
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	This application discloses microorganisms and methods of producing GNAQ/GNA11 inhibitors and methods of making antibody drug conjugates of anti-PMEL17 antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The disclosure also relates to formulations comprising antibody drug conjugates of anti-PMEL17 antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor and methods of treating or preventing cancer using the formulations. Esta solicitud desvela microorganismos y métodos de producción de inhibidores de GNAQ/GNA11 y métodos de fabricación de conjugados anticuerpo-fármaco de anticuerpos anti-PMEL17 o fragmentos de unión a antígeno conjugados con un inhibidor de GNAQ/GNA11. La divulgación también se refiere a formulaciones que comprenden conjugados anticuerpo-fármaco de anticuerpos anti-PMEL17 o fragmentos de unión a antígeno conjugados con un inhibidor de GNAQ/GNA11 y métodos de tratamiento o prevención del cáncer usando las formulaciones.