TEAD INHIBITORS

The present invention relates to a compound of formula (I) wherein A, Z, L, R1, R2, R3, R4, R5 and R33 are as defined in claim 1, or a pharmaceutically acceptable salt thereof. The compounds of formula (I) possess utility as inhibitors of TEAD. The compounds are useful as medicaments in the treatmen...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	PIETIKÄINEN Pekka, SIPILÄ Julius, WOHLFAHRT Gerd, AHLMARK Marko, RUMMAKKO Petteri, DIN BELLE David, NOUTSIAS Dimitris
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to a compound of formula (I) wherein A, Z, L, R1, R2, R3, R4, R5 and R33 are as defined in claim 1, or a pharmaceutically acceptable salt thereof. The compounds of formula (I) possess utility as inhibitors of TEAD. The compounds are useful as medicaments in the treatment of diseases or conditions wherein inhibition of TEAD is desired, such as cancer and chronic pain. La presente invención se refiere a un compuesto de la fórmula (I) (ver Fórmula) en donde A, Z, L, R1, R2, R3, R4, R5 y R33 son como se definen en la reivindicación 1, o una sal farmacéutica aceptable del mismo. Los compuestos de la fórmula (I) poseen utilidad como inhibidores del TEAD. Los compuestos son útiles como medicamentos en el tratamiento de enfermedades o condiciones en donde se desea la inhibición del TEAD, como el cáncer y el dolor crónico.