3,4-DIHYDRO-2,7-NAPHTHYRIDINE-1,6(2H,7H)-DIONES AS MEK INHIBITORS

3,4-DIHYDRO-2,7-NAPHTHYRIDINE-1,6(2H,7H)-DIONES AS MEK INHIBITORS

The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and comp...

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Hauptverfasser: BOYS Mark Laurence, KNAPP Ellen Margaret, REN Li, COWDREY Connor James, KELLUM Alex Andrew, DAHLKE Joshua Ryan, WITKOS Faith Elizabeth, BLANCHE Sydney Taylor, O''LEARY Jacob Matthew, FULTON Jennifer Lynn, MORENO David Austin, ALLEN Shelley, BLAKE James Francis, DOERNER BARBOUR Patrick Michael, CLARK Wesley Dewitt
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7- methyl-3,4- dihydro-2,7-naphthyridine-1,6(2H,7H)-dione. La invención se refiere a un compuesto de la Fórmula I (ver Fórmula) o una sal aceptable desde el punto de vista farmacéutico de este, en donde R1, R2, R3 y R4 son como se definen en la presente; la invención se refiere además a composiciones farmacéuticas que comprenden dichos compuestos y sales, y a métodos y usos de dichos compuesto, sales y composiciones para el tratamiento del crecimiento celular anormal, que incluye cáncer, en un sujeto que lo necesita; la invención se refiere además a formas sólidas de 8-((2-fluoro-4-(metiltio)fenil)amino)-2-(2-hidro xietoxi)-7-metil-3,4-dihidro-2,7-naftiridin-1,6(2H,7H)-diona.