MULTIPARAMETER MATERIALS, METHODS AND SYSTEMS FOR ENHANCED BIOREACTOR MANUFACTURE

Methods for determining glycation on a molecule and/or a glycan structure on a glycosylated molecule through the use of a combination of spectroscopic analysis and chemometric modeling are described. In addition, methods and systems for producing a molecule with a desired level of glycation, includi...

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Hauptverfasser:	RAFFERTY Carl, HAYES Ronan, RANA Pushpraj, O''MAHONY-HARTNETT Caitlin, TROUT Daniel A, RODE Christopher W, BALSS Karin M, CLARK Kevin, MADDEN Fiona, MASLANKA Francis C, MCCARTHY Barry J, GRATSIA Emmanouela, MO Jingjie
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
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Beschreibung
Zusammenfassung:	Methods for determining glycation on a molecule and/or a glycan structure on a glycosylated molecule through the use of a combination of spectroscopic analysis and chemometric modeling are described. In addition, methods and systems for producing a molecule with a desired level of glycation, including a non-glycated molecule, and/or a desired level of a glycan structure on a glycosylated molecule are described. Se describen métodos para determinar la glicación en una molécula y/o una estructura de glicano en una molécula glicosilada a través del uso de una combinación de análisis espectroscópico y modelado quimiométrico. Además, se describen métodos y sistemas para producir una molécula con un nivel deseado de glicación, que incluye una molécula no glicada, y/o un nivel deseado de una estructura de glicano en una molécula glicosilada.