METHODS OF REDUCING NEUROPATHY AND NEUROPATHIC SYMPTOMS AND TREATING CANCER

Disclosed herein are methods for reducing neuropathy and neuropathic symptoms and/or promoting neurogenesis, neuritogenesis, neuroprotection and neuroregeneration using saposin C-phospholipid compositions. Also disclosed are methods for treating cancer by administering a saposin C-phospholipid nanov...

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Bibliographische Detailangaben
Hauptverfasser:	WOLFE Darren P, CURRY, III Richard Charles, WESOLOWSKI Robert, NOONAN Anne Mary, TAKIGIKU Ray, GAZDA Michael, TAPOLSKY Gilles Hugues, CRUZE, III Charles A
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed herein are methods for reducing neuropathy and neuropathic symptoms and/or promoting neurogenesis, neuritogenesis, neuroprotection and neuroregeneration using saposin C-phospholipid compositions. Also disclosed are methods for treating cancer by administering a saposin C-phospholipid nanovesicle formulation and one or more antineoplastic agents or immune checkpoint inhibitors, and kits for the treatment of cancer comprising, in separate containers, (a) a saposin C-phospholipid pharmaceutical composition, and (b) a pharmaceutical composition containing an antineoplastic agent or a pharmaceutical composition containing an immune checkpoint inhibitor. En el presente documento se describen métodos para reducir la neuropatía y síntomas neuropáticos y/o promover neurogénesis, neuritogénesis, neuroprotección y neuroregeneración usando composiciones de saposina C-fosfolípido. También se describen métodos para el tratamiento contra el cáncer al ser administrable una formulación de nanovesículas de saposina C-fosfolípido y uno o más agentes antineoplásicos o inhibidores de puntos de control inmunitario, y kits para el tratamiento contra el cáncer que comprenden, en recipientes separados, (a) una composición farmacéutica de saposina C-fosfolípido, y (b) una composición farmacéutica que contiene un agente antineoplásico o una composición farmacéutica que contiene un inhibidor de puntos de control inmunitario.