ANTIBODY COMPOSITIONS AND METHODS OF USE THEREOF

The disclosure provides pharmaceutical compositions comprising an antibody and at least two antioxidants. In some aspects, pharmaceutical composition is formulated for subcutaneous delivery. In some aspects, the pharmaceutical composition further comprises an endoglycosidase hydrolase enzyme. Other...

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Bibliographische Detailangaben
Hauptverfasser: KHOSSRAVI Mehrnaz, HART Scott Aaron, HABY Thomas Arthur, MURTHY Bindu Purnima, SANGHAVI Kinjal, ZHAO Xiaochen, BELLO Akintunde, VEZINA Heather Elizabeth, HUANG Masano, ARAS Urvi Ashish, ROY Amit, MANTRI Rao Venkatramana
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:The disclosure provides pharmaceutical compositions comprising an antibody and at least two antioxidants. In some aspects, pharmaceutical composition is formulated for subcutaneous delivery. In some aspects, the pharmaceutical composition further comprises an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering the pharmaceutical composition. La descripción proporciona composiciones farmacéuticas que comprenden un anticuerpo y al menos dos antioxidantes. En algunos aspectos, la composición farmacéutica está formulada para la administración subcutánea. En algunos aspectos, la composición farmacéutica comprende además una enzima de endoglicosidasa hidrolasa. Otros aspectos de la presente descripción están dirigidos a los métodos de administración subcutánea de la composición farmacéutica.