MACROCYCLIC BRANCHED 3-FLUORO-BUT-3-ENAMIDES AS INHIBITORS OF MCL-1

The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer. La presente invención se relaciona con agent...

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Bibliographische Detailangaben
Hauptverfasser:	SURKYN Michel, ROMBOUTS Frederik Jan Rita, JOUFFROY Matthieu Dominique, JERHAOUI Soufyan, HSIAO Meng- Yang
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to pharmaceutical agents of formula (I) useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer. La presente invención se relaciona con agentes farmacéuticos de la Fórmula (I) útiles para terapia y/o profilaxis en un sujeto, composición farmacéutica que comprende tales compuestos, y su uso como inhibidores de MCL-1, útiles para tratar enfermedades tales como cáncer.