HETERODIMERIC PSMA AND CD3-BINDING BISPECIFIC ANTIBODIES

The present disclosure relates to antibodies that specifically bind to a tumor-associated antigen (TAA) such as PSMA and/or CD3, including bispecific antibodies that bind to a TAA (e.g., PSMA( and CD3, and compositions comprising the same. These antibodies are useful for enhancing immune responses a...

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Hauptverfasser: HERNANDEZ-HOYOS Gabriela, MISHER Lynda, BIENVENUE David Leonard, GROSS Jane, PAVLIK Peter
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:The present disclosure relates to antibodies that specifically bind to a tumor-associated antigen (TAA) such as PSMA and/or CD3, including bispecific antibodies that bind to a TAA (e.g., PSMA( and CD3, and compositions comprising the same. These antibodies are useful for enhancing immune responses and for the treatment of disorders, including solid tumor cancers, for example, by increasing tumor localization. La presente descripción se relaciona con anticuerpos que se unen específicamente a un antígeno asociado a un tumor (TAA) tal como PSMA y/o CD3, incluidos anticuerpos biespecíficos que se unen a un TAA (p. ej., PSMA) y CD3, y composiciones que comprenden los mismos. Estos anticuerpos son útiles para potenciar las respuestas inmunitarias y para el tratamiento de trastornos, incluidos los cánceres de tumores sólidos, por ejemplo, aumentando la localización del tumor.