A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4 -CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1 -(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO )PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE

A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4 -CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1 -(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO )PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE

The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phen yl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8 ,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotet radecin-5(6H)-one: C...

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Hauptverfasser: WAGSCHAL Simon Albert, CAO Duy Chi Trung, LEMAIRE Sebastien François Emmanuel, MOWER Matthew Penfield, PEREGO Luca Alessandro, BROGGINI Diego Fernando Domenico, GALLAGHER William P, WEI Carolyn S, KOSCHKER Philipp, ZHDANKO Alexander, WISNIEWSKI Steven R, MUKHERJEE Subha, SINGH Amarjit, CHERNICHENKO Kostiantyn, TRAN Ngoc Duc, SCHMALZBAUER Björn, XIOURAS Christos, BEN HAÏM Cyril, ORTIZ Adrian, ZHENG Bin, CUNIERE Nicolas, JAMISON Christopher Robert, SKLIAR Dimitri, EASTGATE Martin D, KOLOTUCHIN Sergei, MATCHA Kiran, LUO Helen Y, SFOUGGATAKIS Chris, REUTER Karl, RAHMANI Ramdane, JUSSEAU Xavier Jean-marie
Format: Patent
Sprache:eng ; spa
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APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phen yl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-1,4,7,8 ,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotet radecin-5(6H)-one: Compound (I). La presente solicitud se refiere en general a varios procesos para la preparación de (6R, 10S)-10-{4-[5-cloro-2-(4- cloro-1H-1,2,3-triazol-1-il)fenil]-6-oxo-1(6H)-pirimidinil}- 1-(difluorometil) -6-metil-1,4,7,8,9,10-hexahidro-11,15- (meteno)pirazolo[4,3 -b][1,7]diazaciclotetradecina-5(6H)-ona: Compuesto (I).