COMPOSITIONS AND METHODS FOR IN VIVO GENERATION OF CAR EXPRESSING CELLS

Aspects of this disclosure relate generally to the use of biomaterials for the in vivo generation of CAR expressing cells. In some embodiments, the biomaterials comprise one or more of a cell recruitment composition, a viral vector, and/or a cell activation agent. Los aspectos de esta divulgación se...

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Hauptverfasser:	BARDROFF Michael, KOSHY Sandeep Tharian, APSUNDE Tushar Dattu, BRIDGEMAN Chris, LEE Cameron Chuck-munn, GUYOT Justine, GRANDA Brian Walter, MILLER Sandra, DRANOFF Glenn, PRICE Andrew Patrick, TREANOR Louise Mary, CANHAM Stephen Michael, JAYASHANKAR Shyamali, SKEGRO Darko, MELLES Yoel, CEBE Regis, RAYO Amy, YANG Jennifer, BROGGI Maria Anna Sofia
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Aspects of this disclosure relate generally to the use of biomaterials for the in vivo generation of CAR expressing cells. In some embodiments, the biomaterials comprise one or more of a cell recruitment composition, a viral vector, and/or a cell activation agent. Los aspectos de esta divulgación se refieren en general al uso de biomateriales para la generación in vivo de células que expresan CAR. En algunas modalidades, los biomateriales comprenden uno o más de una composición de reclutamiento celular, un vector viral y/o un agente de activación celular.