PROCESSES FOR PREPARING MODULATORS OF ALPHA-1 ANTITRYPSIN
This disclosure provides large-scale processes for preparing a modulator of alpha-1 antitrypsin (AAT) activity that may be useful for treating alpha-1 antitrypsin deficiency (AATD), such as 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran -4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compou...
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| creator | BLIGH Cavan Mckeon GIACOMETTI Robert Daniel ROEPER Stefanie LAWS Stephen W LOOKER Adam HARRISON Cristian |
| description | This disclosure provides large-scale processes for preparing a modulator of alpha-1 antitrypsin (AAT) activity that may be useful for treating alpha-1 antitrypsin deficiency (AATD), such as 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran -4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1), 3-[5-(4-fluorophenyl)-6-isopropyl-1H-pyrrolo[2,3-f]indazol-7-yl ]propanoic acid (Compound 2), or a pharmaceutically acceptable salt of any of the foregoing.
La presente descripción proporciona procesos a gran escala para preparar un modulador de la actividad de la alfa-1 antitripsina (AAT) que puede ser útil para tratar la deficiencia de alfa-1 antitripsina (AATD), tal como ácido 4- (5-(4-fluorofenil)-6-(tetra hidro-2H-piran -4-il)-1,5- dihidropirrolo[2,3-f]indazol-7-il)benzo ico (Compuesto 1), ácido 3-[5-(4-fluorofenil)-6-isopropil-1H-pirro lo[2,3- f]indazol-7-il]propanoico (Compuesto 2), o una sal farmacéuticamente aceptable de cualquiera de los anteriores. |
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La presente descripción proporciona procesos a gran escala para preparar un modulador de la actividad de la alfa-1 antitripsina (AAT) que puede ser útil para tratar la deficiencia de alfa-1 antitripsina (AATD), tal como ácido 4- (5-(4-fluorofenil)-6-(tetra hidro-2H-piran -4-il)-1,5- dihidropirrolo[2,3-f]indazol-7-il)benzo ico (Compuesto 1), ácido 3-[5-(4-fluorofenil)-6-isopropil-1H-pirro lo[2,3- f]indazol-7-il]propanoico (Compuesto 2), o una sal farmacéuticamente aceptable de cualquiera de los anteriores.</description><language>eng ; spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230515&DB=EPODOC&CC=MX&NR=2023001084A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230515&DB=EPODOC&CC=MX&NR=2023001084A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BLIGH Cavan Mckeon</creatorcontrib><creatorcontrib>GIACOMETTI Robert Daniel</creatorcontrib><creatorcontrib>ROEPER Stefanie</creatorcontrib><creatorcontrib>LAWS Stephen W</creatorcontrib><creatorcontrib>LOOKER Adam</creatorcontrib><creatorcontrib>HARRISON Cristian</creatorcontrib><title>PROCESSES FOR PREPARING MODULATORS OF ALPHA-1 ANTITRYPSIN</title><description>This disclosure provides large-scale processes for preparing a modulator of alpha-1 antitrypsin (AAT) activity that may be useful for treating alpha-1 antitrypsin deficiency (AATD), such as 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran -4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1), 3-[5-(4-fluorophenyl)-6-isopropyl-1H-pyrrolo[2,3-f]indazol-7-yl ]propanoic acid (Compound 2), or a pharmaceutically acceptable salt of any of the foregoing.
La presente descripción proporciona procesos a gran escala para preparar un modulador de la actividad de la alfa-1 antitripsina (AAT) que puede ser útil para tratar la deficiencia de alfa-1 antitripsina (AATD), tal como ácido 4- (5-(4-fluorofenil)-6-(tetra hidro-2H-piran -4-il)-1,5- dihidropirrolo[2,3-f]indazol-7-il)benzo ico (Compuesto 1), ácido 3-[5-(4-fluorofenil)-6-isopropil-1H-pirro lo[2,3- f]indazol-7-il]propanoico (Compuesto 2), o una sal farmacéuticamente aceptable de cualquiera de los anteriores.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAMCPJ3dg0Odg1WcPMPUggIcg1wDPL0c1fw9XcJ9XEM8Q8KVvB3U3D0CfBw1DVUcPQL8QwJigwI9vTjYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxvhFGBkbGBgaGBhYmjsZEKQIA9YspYA</recordid><startdate>20230515</startdate><enddate>20230515</enddate><creator>BLIGH Cavan Mckeon</creator><creator>GIACOMETTI Robert Daniel</creator><creator>ROEPER Stefanie</creator><creator>LAWS Stephen W</creator><creator>LOOKER Adam</creator><creator>HARRISON Cristian</creator><scope>EVB</scope></search><sort><creationdate>20230515</creationdate><title>PROCESSES FOR PREPARING MODULATORS OF ALPHA-1 ANTITRYPSIN</title><author>BLIGH Cavan Mckeon ; GIACOMETTI Robert Daniel ; ROEPER Stefanie ; LAWS Stephen W ; LOOKER Adam ; HARRISON Cristian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_MX2023001084A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; spa</language><creationdate>2023</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>BLIGH Cavan Mckeon</creatorcontrib><creatorcontrib>GIACOMETTI Robert Daniel</creatorcontrib><creatorcontrib>ROEPER Stefanie</creatorcontrib><creatorcontrib>LAWS Stephen W</creatorcontrib><creatorcontrib>LOOKER Adam</creatorcontrib><creatorcontrib>HARRISON Cristian</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BLIGH Cavan Mckeon</au><au>GIACOMETTI Robert Daniel</au><au>ROEPER Stefanie</au><au>LAWS Stephen W</au><au>LOOKER Adam</au><au>HARRISON Cristian</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESSES FOR PREPARING MODULATORS OF ALPHA-1 ANTITRYPSIN</title><date>2023-05-15</date><risdate>2023</risdate><abstract>This disclosure provides large-scale processes for preparing a modulator of alpha-1 antitrypsin (AAT) activity that may be useful for treating alpha-1 antitrypsin deficiency (AATD), such as 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran -4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1), 3-[5-(4-fluorophenyl)-6-isopropyl-1H-pyrrolo[2,3-f]indazol-7-yl ]propanoic acid (Compound 2), or a pharmaceutically acceptable salt of any of the foregoing.
La presente descripción proporciona procesos a gran escala para preparar un modulador de la actividad de la alfa-1 antitripsina (AAT) que puede ser útil para tratar la deficiencia de alfa-1 antitripsina (AATD), tal como ácido 4- (5-(4-fluorofenil)-6-(tetra hidro-2H-piran -4-il)-1,5- dihidropirrolo[2,3-f]indazol-7-il)benzo ico (Compuesto 1), ácido 3-[5-(4-fluorofenil)-6-isopropil-1H-pirro lo[2,3- f]indazol-7-il]propanoico (Compuesto 2), o una sal farmacéuticamente aceptable de cualquiera de los anteriores.</abstract><oa>free_for_read</oa></addata></record> |
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| title | PROCESSES FOR PREPARING MODULATORS OF ALPHA-1 ANTITRYPSIN |
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