PROCESSES FOR PREPARING MODULATORS OF ALPHA-1 ANTITRYPSIN

PROCESSES FOR PREPARING MODULATORS OF ALPHA-1 ANTITRYPSIN

This disclosure provides large-scale processes for preparing a modulator of alpha-1 antitrypsin (AAT) activity that may be useful for treating alpha-1 antitrypsin deficiency (AATD), such as 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran -4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compou...

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Bibliographische Detailangaben
Hauptverfasser: BLIGH Cavan Mckeon, GIACOMETTI Robert Daniel, ROEPER Stefanie, LAWS Stephen W, LOOKER Adam, HARRISON Cristian
Format: Patent
Sprache:eng ; spa
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:This disclosure provides large-scale processes for preparing a modulator of alpha-1 antitrypsin (AAT) activity that may be useful for treating alpha-1 antitrypsin deficiency (AATD), such as 4-(5-(4-fluorophenyl)-6-(tetrahydro-2H-pyran -4-yl)-1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid (Compound 1), 3-[5-(4-fluorophenyl)-6-isopropyl-1H-pyrrolo[2,3-f]indazol-7-yl ]propanoic acid (Compound 2), or a pharmaceutically acceptable salt of any of the foregoing. La presente descripción proporciona procesos a gran escala para preparar un modulador de la actividad de la alfa-1 antitripsina (AAT) que puede ser útil para tratar la deficiencia de alfa-1 antitripsina (AATD), tal como ácido 4- (5-(4-fluorofenil)-6-(tetra hidro-2H-piran -4-il)-1,5- dihidropirrolo[2,3-f]indazol-7-il)benzo ico (Compuesto 1), ácido 3-[5-(4-fluorofenil)-6-isopropil-1H-pirro lo[2,3- f]indazol-7-il]propanoico (Compuesto 2), o una sal farmacéuticamente aceptable de cualquiera de los anteriores.