S100 PROTEINS AS NOVEL THERAPEUTIC TARGETS IN MYELOPROLIFERATIVE NEOPLASMS

The current invention pertains an inhibitor of an S100 protein, preferably an inhibitor of an S100A8 or S100A9 protein, for the prevention or treatment of a myeloproliferative neoplasm. In particular, the invention pertains to an inhibitor of an S100A8 orS100A9 protein, for the prevention ortreatment of primary myelofibrosis. The invention further pertains to an diagnostic method for identifying a subject suffering from a myeloproliferative neoplasm, comprising a step of detecting the presence of an S100 protein, preferably S100A8 or S100A9, in a biological sample.The current invention pertains an inhibitor of an S100 protein, preferably an inhibitor of an S100A8 or S100A9 protein, for the prevention or treatment of a myeloproliferative neoplasm. In particular, the invention pertains to an inhibitor of an S100A8 orS100A9 protein, for the prevention ortreatment of primary myelofibrosis. The invention further pertains to an diagnostic method for identifying a subject suffering from a myeloproliferative neoplasm, comprising a step of detecting the presence of an S100 protein, preferably S100A8 or S100A9, in a biological sample. The present invention relates to a new multimodal ethylene copolymer (P), to the use of the copolymer in film applications and to a film comprising the copolymer of the invention. La presente invención se refiere a un inhibidor de una proteína S100, preferiblemente un inhibidor de una proteína S100A8 o S100A9, para la prevención o el tratamiento de una neoplasia mieloproliferativa. En particular, la invención se refiere a un inhibidor de una proteína S100A8 o S100A9 para la prevención o el tratamiento de la mielofibrosis primaria. La invención se refiere además a un método de diagnóstico para identificar a un sujeto que padezca una neoplasia mieloproliferativa, que comprende un paso de detección de la presencia de una proteína S100, preferiblemente S100A8 o S100A9, en una muestra biológica.