METHODS FOR IMPROVING THE HEALTH OF PORCINE SPECIES BY TARGETED INACTIVATION OF CD163

The present disclosure relates methods and compositions useful for prevention of porcine reproductive and respiratory syndrome virus (PRRSv) in animals, including animals of the species Sus scrofa. The present teachings relate to swine wherein at least one allele of a CD163 gene has been inactivated...

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Bibliographische Detailangaben
Hauptverfasser:	CHRISTIANSON William Thomas, CULBERTSON Matthew Scott, BURGER Brian, BEATON Benjamin, LIGHTNER Jonathan Edward, BARNES Dylan, CIGAN Andrew Mark, CAMPBELL Matthew
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure relates methods and compositions useful for prevention of porcine reproductive and respiratory syndrome virus (PRRSv) in animals, including animals of the species Sus scrofa. The present teachings relate to swine wherein at least one allele of a CD163 gene has been inactivated, and to specific methods and nucleic acid sequences used in gene editing to inactivate the CD163 gene. Swine wherein both alleles of the CD163 gene are inactivated are resistant to porcine reproductive and respiratory syndrome virus (PRRSv). Elite lines comprising homozygous CD163 edited genes retain their superior properties. La presente divulgación se refiere a procedimientos y composiciones útiles para la prevención del virus del síndrome respiratorio y reproductivo porcino (PRRSv) en animales, que incluye animales de la especie Sus scrofa. Las presentes enseñanzas se refieren a cerdos en los que se ha inactivado al menos un alelo de un gen CD163, y a procedimientos específicos y secuencias de ácidos nucleicos que se usan en la edición de genes para inactivar el gen CD163. Los cerdos en los que ambos alelos del gen CD163 están inactivados son resistentes al virus del síndrome respiratorio y reproductivo porcino (PRRSv). Las líneas de élite que comprenden genes CD163 editados homocigóticos conservan sus propiedades superiores.