DRUG ANTIBODY CONJUGATES

Drug conjugates having formula [D-(X)b-(AA)w-(T)g-(L)-]n -Ab wherein: D is a drug moiety having the following formula (I) or a pharmaceutically acceptable salt, ester, solvate, tautomer or stereoisomer thereof, (I) wherein D is covalently attached via a hydroxy or amine group to (X)b if any, or (AA)...

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Bibliographische Detailangaben
Hauptverfasser:	LATORRE LOZANO Alfonso, MARTÍNEZ BARRASA Valentín, FRANCESCH SOLLOSO Andrés M, CUEVAS MARCHANTE María Del Carmen
Format:	Patent
Sprache:	eng ; spa
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Drug conjugates having formula [D-(X)b-(AA)w-(T)g-(L)-]n -Ab wherein: D is a drug moiety having the following formula (I) or a pharmaceutically acceptable salt, ester, solvate, tautomer or stereoisomer thereof, (I) wherein D is covalently attached via a hydroxy or amine group to (X)b if any, or (AA)w if any, or to (T)g if any, or (L); that are useful in the treatment of cancer. Los conjugados de la fórmula [D-(X)b-(AA)w-(T)g-(L)-]n-Ab en donde: D es una porción del fármaco que tiene la siguiente fórmula (I) o una sal, éster, solvato, tautómero o estereoisómero farmacéuticamente aceptable del mismo, (ver Fórmula) (I) en donde D se encuentra unido covalentemente mediante un grupo hidroxi o amino con (X)b si lo hubiera, o (AA)w si lo hubiera, o a T)g si lo hubiera, o a (L); que son útiles en el tratamiento del cáncer.