COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2-ALPHA AND THEIR METHODS OF USE

The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of...

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Hauptverfasser: LI Tengfei, LEBLANC Catherine, MURA Christophe, HINRICHS Jürgen Hans - Hermann, LORTHIOIS Edwige Liliane Jeanne, WILCKEN Rainer, FRITSCH Christine, GERSPACHER Marc, WARIN Nicolas, FAIRHURST Robin Alec, NIETO-OBERHUBER Cristina Montserrat, VAUPEL Andrea, TODOROV Milen, LANGLOIS Jean-baptiste Georges Armand
Format: Patent
Sprache:eng ; spa
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Zusammenfassung:The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of disease. The compounds are inhibitors or modulators of HIF2alpha. La presente invención se refiere a compuestos de fórmula (I) (ver Fórmula) (I) o a una forma de sal farmacéuticamente aceptable de los mismos, en donde los sustituyentes son como se definen en la memoria descriptiva; a intermediarios en la preparación de los compuestos, a las composiciones farmacéuticas que comprenden los compuestos y al uso de los compuestos en el tratamiento de enfermedades. Los compuestos son inhibidores o moduladores de HIF2alfa.